Quick hits (part II)
February 28, 2021 Leave a comment
1) Super-cool interactive NYT feature on ventilation in schools. TL;DR– open the windows.
2) So far, this is in mice, but the potential here is truly world-changing, “First vaccine to fully immunize against malaria builds on pandemic-driven RNA tech”
3) So, I highly doubt this will become law, but, the category of state legislators proposing really stupid laws is now not all restricted to Republicans thanks to the overly-woke left, “California Bill Would Give $1,000 Fines to Retailers With Separate ‘Girls’ and ‘Boys’ Toy Sections”: The proposed bill from Assembly Members Evan Low and Cristina Garcia would require stores to have one unisex section for children’s products and apparel.”
4) Meanwhile, I try and not link too many columns that I just think aren’t all that great, but I had really come around on Michele Goldberg, but this really intellectually dishonest defense of critical race theory really bugged me. This is honestly one of those cases where the commenters (“Readers’ picks always better than the NYT picks) are so much more on-point than the column. Of course, race plays a huge, and long-undervalued role in understanding American history and present society. But that does not mean everything can be boiled down to race nor that we should revert to a pathological racial essentialism where concepts like “meritocracy” and “hard work” are “white.”
5) Interesting to see the LGBT estimates in the latest Gallup. Especially variance by age:
Americans’ Self-Identification as LGBT, by Generation
LGBT Straight/Heterosexual No opinion % % % Generation Z (born 1997-2002) 15.9 78.9 5.2 Millennials (born 1981-1996) 9.1 82.7 8.1 Generation X (born 1965-1980) 3.8 88.6 7.6 Baby boomers (born 1946-1964) 2.0 91.1 6.9 Traditionalists (born before 1946) 1.3 89.9 8.9 GALLUP, 2020
6) This post from Will Wilkinson on his personal evolution from hardcore libertarian to genuine liberal in the context of which ideas are worth having reasoned debate about is really, really interesting.
7) I’ve been happily advocating that soon should be mandating vaccines. This Op-Ed, though, makes a very strong case for why that is far from ideal:
Given the U.S. government’s failure to control the Covid-19 pandemic and the political polarization of public health policies, it may seem wise to allow private corporations to require coronavirus vaccines. After all, it is common for American bosses to manage or attempt to influence the health of their employees through workplace drug testing, company-funded tobacco cessation programs and discounts on gym memberships. Some hospitals and other employers already require their workers to be inoculated for the flu, for example.
But when a company demands that its employees should be vaccinated, this dictate expresses the private power of capital over individuals in ways we should be reluctant to accept. The mere fact that workers and employers are bound together by voluntary contracts doesn’t give bosses license to make medical decisions for their employees. It’s different when the government requires vaccinations, since mandates are typically introduced, removed or modified by democratically elected legislatures, lending legitimacy to public efforts to govern people’s immunization choices…
Governments oversee many actions of private corporations. For example, markets are underpinned by regulatory instruments that uphold contracts, limit monopolies and prevent anti-competitive behavior and insider trading. Thanks to labor laws and worker protections, employer vaccine mandates would also be under at least indirect government influence.
When state governments require vaccinations for school entry, they also specify criteria for exemptions, generally for religious or medical reasons. But establishing criteria for exemptions is beyond the capacities of most private companies, so governments will likely need to do the same for coronavirus vaccine mandates, whether they’re imposed by corporations or legislators. In other words, even private mandates will need government involvement to be operational, let alone effective.
8) This was fascinating and just a perfect case study of why it is truly important to have diverse voices be part of decision-making processes, “In a Changing Military, the Army Eases Its Rules for Women’s Hair: The Army, which is increasingly dependent on female soldiers, has issued new regulations that allow women to wear lipstick and no longer limits their hair to a tight, disciplined bun.”
9) Yglesias makes a really interesting case here, “Back to normal means ignoring the CDC:
The other is that you need to have an appropriate baseline for how public health agencies behave. It is unlikely that the CDC is going to respond to the COVID-19 vaccine rollout by completely revamping their institutional culture. Instead, we need to understand what that institutional culture is, and cover the CDC’s pronouncements accordingly. And the plain fact is that the CDC is extremely scold-y and conservative with its advice.
Nobody actually listens to the CDC
As I’ve mentioned previously, the CDC’s view is not only that pregnant women should abstain from alcohol, but that all women who aren’t on birth control should abstain from alcohol lest they accidentally have a night out drinking without being aware that they are pregnant.
And the context for that, in turn, is that the CDC thinks a man should never have more than two drinks in a day and a woman should never have more than one…
And to be clear, they are quite strict about this — “one drink” equals 12 ounces of 5% ABV beer or one glass of 12% ABV wine. I don’t know anything about wine, but this Real Simple article says that a normal chardonnay, pinot gris, or sauvignon blanc from California has ABV in the 13.5-14.5% range. So a woman who drinks a single glass of white wine is violating CDC guidelines. A Lagunitas IPA is 6.2% ABV, so a woman who drinks one is violating CDC guidelines. If a couple of guys split a six-pack while watching a football game, they are blowing through the guidelines.
I’m not here to say the guidelines are wrong. My understanding is that alcohol is in fact very hazardous to human health.
All I am saying is that we manage as a society to have a situation where these guidelines just kind of exist as a social fact. Libertarians don’t scream at the CDC for advising people to be healthy, and science journalists don’t scream at people for drinking more than this.
According to the federal government’s food safety guidelines:
All hamburgers should be cooked to at least 160 degrees (i.e., well done)
All steaks should be cooked to at least 145 degrees (i.e., medium)
All eggs should have firm yolks (i.e., no sunny-side up)
I am not a foodie snob who judges people for eating well-done meat. But my personal preference is medium-rare. And lots of people eat medium-rare meat. And restaurants serve it. And recipes call for it. I personally know many people who think that we should “listen to the experts” and “science is real” who enjoy eating eggs with runny yolks.
But beyond cooking temperature, any scientist would tell you that a hamburger is not a very healthy thing to eat! But also the people eating the burgers are not confused about this. Throughout the pandemic, pretty much every Saturday I take my kid out for a hike or nature walk somewhere and then take him to a McDonald’s Drive-Thru. I don’t think the government should try to stop me from buying him his Happy Meal. But I also don’t think the government should try to gaslight me into believing McDonald’s is a healthy lunch…
“This isn’t over yet,” Derek Thompson says. “Don’t eat the marshmallow. We still need masks and distancing. We still need to accelerate vaccinations.”
I agree with all that. But in that sense, I think we are being ill-served by political leadership that has reversed Trump’s flagrant dismissal of public health guidance in favor of the excessive deference of “a woman should never drink a full glass of white wine.”
It’s fine that the public health agencies are going to urge caution essentially indefinitely. But that means we need Joe Biden to clearly say something like:
I anticipate that a vaccine will be available to any adult who wants one around Day X, or at worst Day Y.
That won’t mean the virus magically vanishes, but it does mean that a few weeks after we achieve Vaccination for All Who Want It, the official national emergency will end.
In post-emergency America, it will still be true that virologists recommend washing your hands every time you pet your dog, but personally I’m going to return to my relaxed, no-malarkey lifestyle.
Specifically, I have been wearing a mask in public even though I was vaccinated a while ago because I’m trying to set a good example, but once vaccines are broadly available I will stop doing that.
I understand that everyone is impatient, but I’m asking you all to wait for six more weeks, not seven more months.
Then, I dunno, make a good-hearted joke. Say, “Fauci and Trump disagreed about a lot of stuff, but I read in Washingtonian that way before the pandemic Trump would obsessively hand sanitize before drinking a glass of Diet Coke, and Fauci probably thought that was great. And maybe we should all be more healthy all the time. But right now I’m gonna go get some Jeni’s with Nancy Pelosi.”
The nature of modern social media tends to polarize everything. And throughout the pandemic, the discourse has been pulled between “it’s just the flu” and public health stridency. And for most of the year, stridency has been approximately correct. But the more light there is at the end of the tunnel, the more tempting it becomes to eat the marshmallow, while at the same time the gap between public health stridency and reasonable cost-benefit analysis also grows. It’s not really the job of Fauci or the CDC to strike that balance, but it is the country’s elected leadership’s job, and you can’t just outsource it to them.
10) Crazy story, “Is ‘Avalanche’ the Answer to a 62-Year-Old Russian Mystery Over 9 Deaths? Was it U.F.O.s? Yeti? The K.G.B.? The riddle of who or what killed nine young hikers has inspired conspiracy theories for decades. Two scientists now say a natural disaster may be to blame.”
11) Paul Waldman, “Republicans are barking up the wrong voter suppression tree”
As the Brennan Center for Justice recently reported, Republicans at the state level have introduced a wave of voter suppression measures, including cutting back early voting and making it harder to register. But vote-by-mail has been their primary focus:
Nearly half of restrictive bills introduced this year seek to limit mail voting. Legislators are taking aim at mail voting at every stage, with proposals to circumscribe who can vote by mail, make it harder to obtain mail ballots, and impose hurdles to complete and cast mail ballots.But what if they’re barking up the wrong voter suppression tree?
A new analysis by Emory political scientist Alan Abramowitz suggests they are. While more people voted by mail than ever last November, and more Democrats did than ever, Abramowitz argues that neither party benefited from mail ballots.
He comes to that conclusion by comparing states both to each other and to their results in 2016. Here’s what he found:
- Turnout was up dramatically across the board.
- States that eased their absentee voting rules saw significant increases in mail voting; in other words, people took advantage of voting by mail where they could.
- Where rates of mail voting were high, turnout went up more than states where mail voting was lower.
- But the rate of mail voting had no effect on President Biden’s performance.
In other words, if a state opened up its absentee voting rules, the result would be that turnout would go up, but it wouldn’t end up helping Biden, because turnout went up for both Democrats and Republicans. Biden did better than Hillary Clinton had pretty much everywhere, but that improvement wasn’t a function of whether a state liberalized its absentee voting rules.
12) Really enjoyed this on the science behind the polar vortex (very cool images here, too).
13) Very science-y, but very cool article from back in September, “The tiny tweak behind COVID-19 vaccines“
But there’s a third, more subtle secret to their success: a tiny but oh-so-important tweak to a critical viral component called the spike protein.
Viruses multiply by dumping their genes into our cells and hijacking our cellular machinery to crank out new virus particles. But first, they need a doorway into our cells. Coronaviruses are studded with spikes, which grab hold of proteins decorating our own cells like doorknobs. Once attached, the spike undergoes a dramatic transformation, stretching before partially turning inside out to forcefully fuse with our cells.
Scientists believe that for COVID-19 vaccines to be effective, our immune systems must develop antibodies that prevent this fusion. Such antibodies must target the spike protein in its aptly named prefusion conformation. Unfortunately for vaccine developers, spike proteins are liable to spring from their stubby prefusion shape into their elongated postfusion form on a hair trigger.
Fortuitously, Graham and a former postdoc, Jason McLellan, devised a solution to this problem before the pandemic. Through a bit of structural biology and persistent protein engineering, McLellan discovered that adding two prolines—the most rigid of the 20 amino acids—to a key joint of a vaccine’s spike protein could stabilize the structure’s prefusion shape. This 2P mutation worked in preclinical studies of Graham and Moderna’s MERS vaccine, so they applied it to Moderna’s COVID-19 vaccine.
As Norbert Pardi, an mRNA vaccine scientist at the University of Pennsylvania, puts it, we’re “very lucky, actually,” that scientists worked out the 2P mutation for a MERS vaccine before the COVID-19 pandemic. “It wouldn’t be possible to go so fast with the Moderna vaccine otherwise.”
Other companies, including Johnson & Johnson, Novavax, and Pfizer, are hoping the 2P mutation works for their COVID-19 vaccines too.
The 2P mutation might quite literally be the smallest detail that could make or break the first generation of COVID-19 vaccines. It’s an easy enough tweak to add during the early stages of vaccine design. And if successful, 2P-based vaccines may herald a new generation of vaccines whose molecular makeup is fine-tuned to craft a safer, stronger immune response.
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