1) This was really good, “A Vaccine That Stops Covid-19 Won’t Be Enough: The best vaccines don’t just prevent a disease; they also prevent the pathogen causing the disease from being transmitted. So why aren’t we focusing more on those?”
A vaccine’s ability to forestall a disease is also how vaccine developers typically design — and how regulators typically evaluate — Phase 3 clinical trials for vaccine candidates.
Yet the best vaccines also serve another, critical, function: They block a pathogen’s transmission from one person to another. And this result, often called an “indirect” effect of vaccination, is no less important than the direct effect of preventing the disease caused by that pathogen. In fact, during a pandemic, it probably is even more important.
That’s what we should be focusing on right now. And yet we are not.
Stopping a virus’s transmission reduces the entire population’s overall exposure to the virus. It protects people who may be too frail to respond to a vaccine, who do not have access to the vaccine, who refuse to be immunized and whose immune response might wane over time.
The benefits of this approach have been demonstrated with other pathogens and other diseases…
The U.S. Food and Drug Administration has stated that preventing a SARS-CoV-2 infection is in itself a sufficient endpoint for the Phase 3 trials of vaccine candidates — that it is an acceptable alternative goal to preventing the development of Covid-19. The World Health Organization has said that “shedding/transmission” is as well.
These guidelines are an important signal, especially considering that the F.D.A. has never approved a vaccine based on its effects on infection alone; instead, the agency has focused exclusively on the vaccine’s effectiveness at disease prevention.
And yet vaccine developers do not seem to be heeding this new call.
Based on our review of the Phase 3 tests listed at ClinicalTrials.gov, a database of trials conducted around the world, the primary goal in each of these studies is to reduce the occurrence of Covid-19.
Four of the six Covid-19 vaccine trials for which information is available say they will also evaluate the incidence of SARS-CoV-2 infections among subjects — but only as an ancillary outcome.
This approach is shortsighted: One cannot assume that a vaccine that prevents the development of Covid-19 in a patient will necessarily also limit the risk that the patient will transmit SARS-CoV-2 to other people.
2) Very relatedly, “What if the First Coronavirus Vaccines Aren’t the Best? Dozens of research groups around the world are playing the long game, convinced that their experimental vaccines will be cheaper and more powerful than the ones leading the race today.” Lots of great stuff in here, hard to paste any good quote.
3) I thought we had gotten so much better at this. How are we still having headlines like, “‘Overwhelmed’ Ronnie Long to go free after 44 years. NC to vacate rape conviction.” I mean, I know, but seems like almost two decades now we’ve realized how many awful racist convictions like this there are and it took this long?! Every story like this makes me wonder just how many thousands? tens of thousands? of Americans wrongly languish in prison (for the record, Antonin Scalia, a morally very small man, was convinced it was just a few).
4) Is Skynet upon us? “A Dogfight Renews Concerns About AI’s Lethal Potential”
IN JULY 2015, two founders of DeepMind, a division of Alphabet with a reputation for pushing the boundaries of artificial intelligence, were among the first to sign an open letter urging the world’s governments to ban work on lethal AI weapons. Notable signatories included Stephen Hawking, Elon Musk, and Jack Dorsey.
Last week, a technique popularized by DeepMind was adapted to control an autonomous F-16 fighter plane in a Pentagon-funded contest to show off the capabilities of AI systems. In the final stage of the event, a similar algorithm went head-to-head with a real F-16 pilot using a VR headset and simulator controls. The AI pilot won, 5-0.
The episode reveals DeepMind caught between two conflicting desires. The company doesn’t want its technology used to kill people. On the other hand, publishing research and source code helps advance the field of AI and lets others build upon its results. But that also allows others to use and adapt the code for their own purposes.
Others in AI are grappling with similar issues, as more ethically questionable uses of AI, from facial recognition to deepfakes to autonomous weapons, emerge.
A DeepMind spokesperson says society needs to debate what is acceptable when it comes to AI weapons. “The establishment of shared norms around responsible use of AI is crucial,” she says. DeepMind has a team that assesses the potential impacts of its research, and the company does not always release the code behind its advances. “We take a thoughtful and responsible approach to what we publish,” the spokesperson adds.
5) As any Slate Political Gabfest fan knows, David Plotz hates pandas! And, now you can read one of his patented anti-panda rants in print:
Another Giant Panda baby at the Zoo, another win for China.
The Giant Panda Mei Xiang gave birth to a cub Friday night at Washington’s National Zoo, and the local and national media are predictably gaga. It’s a “miracle” cub because Mei Xiang’s the oldest American panda to give birth in captivity, and because the zookeepers managed the pregnancy through the pandemic. If the cub lives, it will be her fourth.
China’s Giant Panda lend-lease program is one of the cleverest examples of public diplomacy in the modern world. Exploiting the world’s crush on the black-and-white semi-bears, China rents pandas out to zoos for huge fees — $1 million a year has been reported. The zoos then pay monstrous amounts to feed and care for the animals, $500,000 a year per bear, and undertake captive breeding programs. China owns all cubs, which are repatriated to China at age four and enrolled in China’s elaborate breeding, research, and re-wilding program. (Mei Xiang’s first three offspring were all repatriated to China.)
Americans have addicted themselves to pandas. They’re the main draw for the National Zoo, and also have attracted huge crowds in other cities where they’ve been loaned out, including San Diego and Atlanta.
But why are we duped by them? Pandas are gorgeous, but — as with too-beautiful humans — pandas exploit their beauty to cover up their deep character flaws. Pandas are lazy and ill-tempered. They barely move! (The hours I wasted as a DC schoolkid waiting for one of the pandas to do something, anything — just to lift a paw!) Pandas don’t seem to be interested in their own survival: It takes heroic, hideously expensive efforts to get them to breed. They’re largely indifferent parents. (Don’t get me started about the DC panda that crushed its own newborn.)
Americans are forking over enormous sums of money to China so they can gawp at dumb, brutish supermodel animals. We should be spending those millions on American-made products. How about bison? Or black-footed ferrets? Or manatees? Or pumas? Pumas are plenty gorgeous!
The Trump administration is frantic that TikTok and Huawei are infiltrating the US and hooking Americans on Chinese products. Maybe they should worry about Giant Pandas instead. — DP
6) Good stuff from political scientists, Brian Schaffner, Jesse Rhodes and Raymond J. La Raja, “Why Trump Never Stops Talking About ‘Our Suburbs’”
Why do Black citizens receive worse representation in suburban and rural towns relative to cities? One of the most important insights from our research is that people of color are so disadvantaged in terms of influencing their local governments that they really manage to receive equitable political representation only when their political views are similar to those of the whites in their communities.
This is what political scientists call “coincidental representation,” a dynamic where a group has political power only by virtue of having common interests with another politically powerful group. In most places, it is the white residents who have the actual power to influence local government, so in communities where local officials represent the interests of African-Americans, this is often because of a close correspondence between the policy preferences of African-Americans and those of whites.
This insight helps explain the puzzle of why inequality in representation in cities — as bad as it is — is not nearly as bad as it is in smaller communities.
As the second accompanying chart, based on the 2018 Cooperative Congressional Election Study survey of 60,000 Americans, shows, white Americans who live in big cities tend to be more liberal than whites who live in suburbs and small towns. Nearly 40 percent of whites living in cities identify as ideologically liberal, which is very similar to the percentage of African-Americans who do the same. This means that in many big cities a large fraction of white residents often see eye-to-eye with Black residents, at least in terms of how they identify ideologically.
By contrast, African-Americans who live in America’s suburbs and small towns are still quite liberal, but their white neighbors are much more conservative. In fact, 22 percent of small-town and rural whites identify as liberal while more than half identify as conservative. Because whites tend to hold real political power in suburban and rural communities, their conservative views mean that the chance Black interests will be represented is especially poor.
7) Jennifer Rubin, “The Senate Intelligence Committee’s report really is damning”
Sen. Mark R. Warner (Va.), ranking Democrat on the Senate Intelligence Committee, appeared on television Sunday to discuss the fifth and final volume the committee has published on Russian interference in the 2016 U.S. election on behalf of Donald Trump. Keep in mind that this volume was approved 14 to 1 by the committee, including the chairman who oversaw most of the investigation, Sen. Richard Burr (R-N.C.). Republicans can publicly spin all they like, but the facts are there, nearly unanimously confirmed. The report is replete with damning details of contacts between the Trump campaign (including Roger Stone on the WikiLeaks hack and email dump) and Russian operatives.
Warner explained on “Meet the Press” that there were “unprecedented contacts between Russians and folks on the Trump campaign. The Trump campaign officials welcomed that help.” He added, “Maybe one of the most stunning was the level of detail of the then-campaign manager, Paul Manafort, sharing very specific campaign information with a Russian agent.” Warner said, “We’ll never know what the Russians did with that information. But think about that. A campaign manager sharing with a known Russian agent during the middle of a campaign.” That is quite simply collusion.
The suggestion by Sen. Marco Rubio (R-Fla.) that no collusion occurred and that the committee report actually proves this (!!) ignores the connection between Manafort and Russian intelligence officer Konstantin Kilimnik, the 2016 meeting at Trump Tower among campaign officials and Russian lawyer Natalia Veselnitskaya (who had much closer ties to Russian intelligence than previously was known), Roger Stone’s connection to WikiLeaks, and Trump’s open invitation to Russia to find Hillary Clinton’s emails.
8) One of the great finds of the pandemic for me has been (as you’ve probably noticed) Zeynep Tufekci. Many have noticed. Great profile here in the NYT:
When the Centers for Disease Control and Prevention told Americans in January that they didn’t need to wear masks, Dr. S. Vincent Rajkumar, a professor at the Mayo Clinic and the editor of the Blood Cancer Journal, couldn’t believe his ears.
But he kept silent until Zeynep Tufekci (pronounced ZAY-nep too-FEK-chee), a sociologist he had met on Twitter, wrote that the C.D.C. had blundered by saying protective face coverings should be worn by health workers but not ordinary people.
“Here I am, the editor of a journal in a high profile institution, yet I didn’t have the guts to speak out that it just doesn’t make sense,” Dr. Rajkumar told me. “Everybody should be wearing masks.”
Ms. Tufekci, an associate professor at the University of North Carolina’s School of Information and Library Science with no obvious qualifications in epidemiology, came out against the C.D.C. recommendation in a March 1 tweetstorm before expanding on her criticism in a March 17 Op-Ed article for The New York Times.
The C.D.C. changed its tune in April, advising all Americans above the age of 2 to wear masks to slow the spread of the coronavirus. Michael Basso, a senior health scientist at the agency who had been pushing internally to recommend masks, told me Ms. Tufekci’s public criticism of the agency was the “tipping point.”
In recent years, many public voices have gotten the big things wrong — election forecasts, the effects of digital media on American politics, the risk of a pandemic. Ms. Tufekci, a 40-something who speaks a mile a minute with a light Turkish accent, has none of the trappings of the celebrity academic or the professional pundit. But long before she became perhaps the only good amateur epidemiologist, she had quietly made a habit of being right on the big things.
9) Very sadly, for those of us concerned about American democracy, the headline of this WP Editorial is not hyperbole, “A second Trump term might injure the democratic experiment beyond recovery”
10) OMG Dan Snyder’s Washington Redskins have just been an absolute cesspit of sleazy and grossly sexist behavior. If his record on race was half as bad as it is on gender the other owners would’ve forced him to sell the team.
11) David Frum, “The Platform the GOP Is Too Scared to Publish: What the Republican Party actually stands for, in 13 points”
1) The most important mechanism of economic policy—not the only tool, but the most important—is adjusting the burden of taxation on society’s richest citizens. Lower this level, as Republicans did in 2017, and prosperity will follow. The economy has had a temporary setback, but thanks to the tax cut of 2017, recovery is ready to follow strongly. No further policy change is required, except possibly lower taxes still.
2) The coronavirus is a much-overhyped problem. It’s not that dangerous and will soon burn itself out. States should reopen their economies as rapidly as possible, and accept the ensuing casualties as a cost worth paying—and certainly a better trade-off than saving every last life by shutting down state economies. Masking is useless and theatrical, if not outright counterproductive.
3) Climate change is a much-overhyped problem. It’s probably not happening. If it is happening, it’s not worth worrying about. If it’s worth worrying about, it’s certainly not worth paying trillions of dollars to amend. To the extent it is real, it will be dealt with in the fullness of time by the technologies of tomorrow. Regulations to protect the environment unnecessarily impede economic growth.
12) I love Radiolab. I loved the “The Other Latif Nasser” series (which I belatedly just recently finished). And I love this NYT profile of Radiolab’s Latif Nasser.
13) Some interesting social science, “Partisan ideological attitudes: Liberals are tolerant; the intelligent are intolerant.”
In this article we examine intolerance toward ideological outgroups, conceptualized as the negativity of the attitudes of liberals and conservatives toward their ideological outgroup. We show that conservatives are more ideologically intolerant than liberals and that the more intelligent are more ideologically intolerant than the less intelligent. We also show that the differences between liberals and conservatives and the differences between the more and less intelligent depend on ideological extremity: They are larger for extreme than for moderate ideologists. The implication of these results to questions regarding the relationship between intelligence and ideological intolerance and regarding the relationship between ideology and prejudice are discussed.
But here’s the thing, as much as we may want to really believe the emboldened portion means that this is the type of research that deserves more scrutiny from liberals, not less.
14) This was some really, really cool stuff about the bacterial world, “How Bacteria-Eating Bacteria Could Help Win the War Against Germs: While microscopic and little known, predatory bacteria are among the world’s fiercest and most effective hunters.”
Predatory bacteria carry immense promise in an extraordinarily small package. Deployed under the right circumstances, they could help people beat back harmful microbes in the environment, or purge pathogens from the food supply. Some experts think they could someday serve as a sort of living therapeutic that could help clear drug-resistant germs from ailing patients in whom all other treatments have failed.
But even the small community of researchers who study predatory bacteria have not fully figured out how these cells select and slaughter their hosts. Teasing out those answers could reveal a range of ways to tackle stubborn infections, and provide a window onto predator-prey dynamics at their most microscopic.
15) Ariel Edwards-Levy on reasons to think the polls may be right or may be wrong. I think the extraordinary stability thus far and the record polarization suggests they should be more stable and accurate. Here’s the counter-arguments:
Why This Year Could Be More Volatile
Close elections are more common than they used to be. As FiveThirtyEight’s Geoffrey Skelley notes, the 2016 election marked the eighth consecutive presidential election to end with the popular vote winner ahead by only a single-digit margin, the longest stretch since the Civil War. This is the flip side to the idea of entrenched, highly partisan voter preferences ― big, game-changing swings in the campaign may now be less common, but even smaller shifts could be more likely to affect who actually wins.
We’re in the middle of a pandemic. Coronavirus has dominated this election cycle, eclipsing other campaign stories and personally affecting pretty much everyone in the country. Other issues at the top of voters’ minds, like the economy and health care, are inextricably tied into the pandemic. It also remains a volatile situation. It’s clear that the coronavirus isn’t going away, but we don’t know precisely what the situation will look like in November or whether public opinion on the White House response will remain as negative as it currently is. The precise state of the economy is another unknown, as is the degree to which the abrupt economic shifts this year will impact voters’ thinking.
Campaigning in a pandemic looks different, too, with both jam-packed rallies and door-to-door mobilization efforts scuttled or reimagined. Without modern precedent, it’s difficult to say exactly how those changes will affect voters.
It’s even harder than usual to predict voter turnout. As the election nears, more pollsters will be reporting results among “likely voters.” That requires them to make judgment calls about which people are likely to end up actually voting, relying on factors including voters’ past history of turning out. In the best of circumstances, this determination is somewhat subjective and prone to uncertainty. This time around, with the pandemic upending Election Day as normal, it could be more difficult than ever. That’s without even getting into the possibility that ― as many Democrats fear ― rejected or delayed mail ballots could have an affect on the election. Nearly half of all voters say they expect voting to be difficult this year, according to Pew, up from 15% in fall 2018.
16) OMG, yes this is so frustrating. We should know so much more about Covid, “Why the United States is having a coronavirus data crisis: Political meddling, disorganization and years of neglect of public-health data management mean the country is flying blind.”
Data dashboards in Singapore and New Zealand offer similar windows into how the coronavirus is spreading within their borders. This helps policymakers and citizens determine how to go about daily life, while reducing risks — and provides researchers with a wealth of data. By contrast, the United States offers vanishingly few details on how the disease is spreading, even as people increasingly socialize and travel, and authorities reopen schools and businesses. This state of affairs is frustrating data researchers, who want to help authorities make decisions that can save lives.
“We shouldn’t be flying blind at this point,” says Natalie Dean, a biostatistician at the University of Florida in Gainesville. “We shouldn’t have to speculate.”
Experts told Nature that political meddling, privacy concerns and years of neglect of public-health surveillance systems are among the reasons for the dearth of information in the United States.
17) David Hopkins on the RNC:
This week’s Republican convention did an especially efficient job of encapsulating the current state of the party after four years of Donald Trump’s leadership. In terms of the roster of speakers and the venues at which they spoke, the convention reflected how much the party has become a personal extension of Trump. Among the usual appearances by up-and-coming politicians and regular-citizen testimonials, a long succession of members of the reigning court—including a deputy chief of staff, press secretary, assistant to the president, counselor to the president, personal attorney of the president, and seven Trump family members—dominated the schedule, while the White House itself served as the backdrop to the addresses of both of its current adult occupants.
But the words of these speeches showed how much Trump’s consolidation of power within the party has been accompanied by his adoption of its existing ideological commitments. Speaker after speaker at this week’s convention reinforced standard Republican themes: small government, social traditionalism, veneration of the military and law enforcement, and attacks on “socialism,” the “radical left,” and the news media. Even the president’s children, who might have been expected to spend their stage time sharing family anecdotes intended to create favorable personal impressions of their father, concentrated instead on delivering familiar conservative rhetoric. The occasional heterodoxies of the 2016 Trump campaign, which convinced many pundits and voters at the time that he was pulling the Republican Party to the left on economic policy, are no longer evident.
18) When it comes to a cough, it really is honey for the win.
19) Great interactive feature from Amy Walter on comparing where the polls stand now compared to 2016. The most interesting part:
So, how can this work? If Trump isn’t really losing support from his 2016 base, but Biden is gaining on Clinton’s performance, where are those extra votes coming from?
Answer: a lot is coming from voters who supported third-party/other candidates in 2016. According to the Pew July survey, voters who didn’t support either major party candidate last election are now breaking decidedly for Biden — 55 percent to 39 percent. This group of non-Trump/non-Clinton voters doesn’t get the attention of Obama-Trump voters or suburban moms, but they are a not-insignificant portion of the electorate.
In the 2016 election, the non-Clinton/Trump vote was 6 percent. The Pew validated voter survey put it at 7 percent — so a touch higher than the popular vote. In a race decided on the margins, these voters can shift the race a couple of points. Or, as Pew’s Director of Political Research put it to me in an email, “If nothing else, what this shows is how much 3rd and 4th parties cost Clinton (even though, as I said, our estimate was higher than popular vote).”
20) Plotz again in serious mode, on the second amendment undermining the first amendment:
Guns are the enemy of free speech.
What happens when the Second Amendment meets the First Amendment?
The First Amendment loses.
The BLM protest movement represents the highest expression of the First Amendment. In cities and towns across the US, the people have peaceably assembled to express their grievances. These demonstrations have occasionally degenerated into violence and vandalism — though the violence has been disproportionately instigated and magnified by the police — but they have overwhelmingly been peaceful mass expressions of public discontent.
But what’s increasingly happening — as the murder of two demonstrators in Kenosha tragically proved, and as the Washington Post documents here — is that peaceful demonstrators are encountering heavily armed counterprotesters, often representing alt-right or White nationalist groups.
Here we have the full flowering of the First Amendment — free speech about matters of public urgency — marching headlong the unbridled expansion of the Second Amendment — citizens openly brandishing loaded rifles, often semiautomatic ones, in public places.
These two cherished American principles do not meet on equal footing, because a gun is the opposite of speech. A loaded weapon discourages speech, intimidates, and demands compliance. Even someone who intends no harm with a gun — and I believe that these counterprotesters intend no harm — is quashing the free speech of those around them, because it is impossible to speak openly when someone who hates your opinion is holding a loaded gun near you and telling you to shut up and leave.
It’s right-wing cancel culture.
Guns also intimidate the police, who are proving incapable of keeping order — or unwilling to keep order — when heavily armed counterprotesters decide they want to scare off progressives. This is teaching the gun-bearers that they can dictate what happens in the street because the cops aren’t able to control them the way the cops are all-too-happy to control the peaceful protesters.
Guns can turn what should be harmless exchanges into potential tragedies. We’re still learning exactly what happened in Kenosha, but it appears an unarmed protester verbally accosted Kyle Rittenhouse, and perhaps threw a plastic bag at him, which prompted Rittenhouse to shoot and kill him and then another protester who tried to intervene.
How can citizens possibly engage in the give and take of political argument — the pure heart of the First Amendment — when any wrong move could lead to mass murder? The Second Amendment is squashing the First.
There is no easy solution to this problem. Actually, there is an easy solution, but it’s inconceivable in a country where open-carry is legal almost everywhere, and where there are hundreds of millions of legally owned guns. The easy solution is that citizens should not be permitted to brandish guns in public places.
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